It acts on pain receptors in the central nervous system and the brain to block pain signals to the rest of the body. feeling sleepy, tired, dizzy or "spaced out" - these side effects should wear off within a week or two as your body gets used to tramadol. Do not drink any alcohol as this will make you feel more tired. It's best not to drink alcohol with tramadol as you're more likely to get side effects like feeling sleepy. Headaches should usually go away after the first week of taking tramadol.